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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
Passiflora edulia Sims
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "Passiflora edulia Sims" in MCE Product Catalog:
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1 Cited Publications
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SIM1 is a potent von Hippel-Lindau (VHL)-based trivalent PROTAC capable of degradation for all BET family members, with preference for BRD2 degradation (IC50=1.1 nM; Kd=186 nM). SIM1 shows sustained anti-cancer activity .
Synonyms: SIM010603
Tafetinib (SIM010603) is an oral multi-targets receptor tyrosine kinases inhibitor. Tafetinib inhibitsstem cell factor receptor (Kit),vascular endothelial growth factor receptor-2 (VEGFR-2),platelet-derived growth factor receptor-β (PDGFR-β),glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), andFms-like tyrosine kinase-3 (FLT3)withIC50values between 5.0 and 68.1 nmol/l. Tafetinib inhibits the phosphorylation ofPDGFR-βandVEGFR-2. Tafetinib inhibits endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis .
Cat. No.: HY-D2994
CAS No.: 2434651-49-5
Synonyms: SNAP-MaP555
Cat. No.: HY-131025
CAS No.: 1811539-88-4
Synonyms: JF585, SE; JF585, NHS
Cat. No.: HY-P991195
Synonyms: SIM1811-03
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Cat. No.: HY-141438A
CAS No.: 2719051-98-4
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cis-SIM1 is a negative control of SIM1 .
Cat. No.: HY-19083
CAS No.: 118790-68-4
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SIM-6080 is a calcium antagonist and inhibits the proliferation of rat aortic myocytes and reduces aortic atherosclerosis in rabbits .
Cat. No.: HY-RS12922
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SIM1 Human Pre-designed siRNA Set A contains three designed siRNAs for SIM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS12923
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SIM2 Human Pre-designed siRNA Set A contains three designed siRNAs for SIM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-N5089
CAS No.: 215319-47-4
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Monophenols Neurological Disease Passifloraceae Phenols Plants Disease Research Fields Inflammation/Immunology Passiflora edulia Sims
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Cat. No.: HY-175724
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MBL-IN-6 (Compound 6d) is a Metallo-β-lactamase (MBL) inhibitor with Kis of 2.6 and 0.08 μM for NDM-1 and VIM-2, respectively. MBL-IN-6 has a synergistic activities with Imipenem (HY-B1369A) on MBL-producing clinical isolates (such as E. coli SI-M001, K. pneumonia T2301 and S. marcescens SI-1591) with MICs of 2-64 μg/mL. MBL-IN-6 does not have off-target effects without ACE-1 inhibition activity. MBL-IN-6 can be used for antimicrobial resistance research .
Cat. No.: HY-N19993
Synonyms: Lindera aggregata (Sims) kosterm leaves extract; Combined spicebush leaves extract
Cat. No.: HY-181526
CAS No.: 3099101-40-0
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Sim-9 is a covalent allosteric inhibitor of interferon regulatory factor 3 (IRF3). Sim-9 binds covalently to the Cys222 residue of IRF3, induces its conformational change, blocks its interactions with TRIF, MAVS and STING, and inhibits IRF3 homodimerization and type I interferon response. Sim-9 exhibits significant anti-inflammatory, organ-protective and survival benefits in mouse models of sepsis and acute pancreatitis. Sim-9 can be used for research related to inflammatory diseases .
Cat. No.: HY-RS18152
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Sim1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sim1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W099647
CAS No.: 14936-66-4
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Cat. No.: HY-184990
CAS No.: 2719051-81-5
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E3 Ligase Ligand-linker Conjugate 239 (Compound 20) is a VHL ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 239 is used for the synthesis of BRD2 PROTAC degrader SIM1 (HY-141438) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
